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EUGENE, Ore. — As he often does, Washington’s Hau’oli Kikaha took a direct route to the quarterback. He met Marcus Mariota at the 42-yard line, and they embraced for a handshake.

“Good game,” Kikaha told the Oregon quarterback. “Keep it going.”

Mariota and the No. 9 Ducks did just that Saturday night.

Washington’s defense missed way too many tackles and had few answers for Oregon’s steam-engine offense, particularly in the first half, as the Ducks rolled over the rival Huskies with a 45-20 victory before a crowd of 57,858 at Autzen Stadium.

The Ducks (6-1, 3-1 Pac-12) have beaten the Huskies 11 years in a row, all by at least 17 points.

“It eats at you,” UW junior receiver Jaydon Mickens said. “Eleven in a row is tough. We know Husky Nation really wanted this one.”

Worse yet, the Huskies (5-2, 1-2) lost starting quarterback Cyler Miles to an apparent concussion and starting running back Dwayne Washington to a chest injury, among other injuries.

Miles threw his first interception of the season in the second quarter and he lost a fumble early in the fourth quarter. Redshirt freshman Troy Williams replaced Miles and scored UW’s final touchdown on a 7-yard run.

Washington’s problem on defense was its inability to slow down the Ducks’ running game, and especially Royce Freeman. Oregon’s 229-pound true freshman who rushed for 169 yards and four touchdowns, stealing some of the spotlight for Mariota, the Ducks’ Heisman hopeful.

With what many believed is their best defense in a decade — and coach Chris Petersen’s 2-0 record against Oregon while he was coaching at Boise State — there was hope among Husky fans that this just might be the year the Huskies could end the streak. Instead, it became just another Oregon rout.

“It’s definitely a special time anytime you can beat the Huskies,” Mariota said.

The Huskies’ defensive plan was to slow down that rushing attack and force Mariota to throw more. Instead, Oregon was able to do pretty much what it wanted in the first half, piling up 380 yards en route to a 28-6 halftime lead.

“Quite frustrating,” said Kikaha, UW’s senior defensive end.

Kikaha had 2.5 sacks on Mariota, with whom Kikaha had become friends this summer. Kikaha has 29.5 sacks for his career, moving him with a half sack of Daniel Te’o-Nesheim for UW’s career lead. Kikaha also had a game-high 10 tackles.

UW senior linebacker John Timu dropped a potential interception on Mariota’s first pass of the game. It didn’t get much better for the UW defense after that.

“They’ve got some fast guys, some athletic guys, but so do we,” UW defensive coordinator Pete Kwiatkowski said. “Without going back to watch the tape, I don’t know if we were pressing or our eyes were down — I don’t know. But we definitely missed way too many tackles tonight.”

Too often, UW’s inability to run the ball effectively on first and second downs left Miles in obvious passing situations on third-and-long.

Oregon outscored UW 21-0 in the second quarter and took a 35-6 lead early in the third quarter.

“They get that train moving and they have you on your heels,” Petersen said. “They’re just as good as anybody in the country. … They do an unbelievable job, and they’ve got maybe the best player in college football.”

The Huskies managed just 133 yards rushing — 3.7 yards per carry — and now have questions about the health of their starting backfield. UW managed just 317 yards of offense to the Ducks’ 554 yards.

“It was too easy (for them),” Petersen said.