Lavon Coleman, Drew Sample and Andre Baccellia are also expected to miss UW's Pac-12 opener at Colorado.

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Washington redshirt freshman Byron Murphy, an emerging star in the Huskies’ defensive secondary, is expected to be sidelined for about six weeks with a broken foot, multiple sources told The Seattle Times.

Murphy sustained the injury — a fracture of the fifth metatarsal — in practice this week. It’s a significant setback for UW’s young secondary as the No. 7 Huskies (3-0) prepare for Saturday’s Pac-12 opener against a Colorado offense that features three senior wide receivers.

A cornerback from Scottsdale, Ariz., Murphy had two interceptions in his debut for the Huskies in their season-opening victory at Rutgers.

Sophomore Austin Joyner is expected to make his first career start in Murphy’s place against Colorado.

Three other UW regulars are expected to sit out at Colorado with injuries: starting wide receiver Andre Baccellia, starting tight end Drew Sample and backup running back Lavon Coleman, who sustained a concussion in practice this week. Baccellia and Coleman could be back next week, sources said. Sample is expected to miss a couple more weeks.

Starting slot receiver Chico McClatcher, who sat out last week’s victory at Fresno State, made the trip to Boulder and is expected to be a game-time decision Saturday night.

With McClatcher, Baccellia and Sample out last week against Fresno State, redshirt freshman Jordan Chin and true freshman tight end Hunter Bryant both had their first career starters.

Backup linebacker D.J. Beavers has been sidelined all season with an Achilles injury and is expected to miss significant time.