Tom Brady led New England to a 20-13 victory over the visiting Buffalo Bills on Monday night. The defending Super Bowl champions are 10-0.

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FOXBOROUGH, Mass. – Tom Brady called out Rex Ryan and then he beat the Bills — again.

After shouting the name of the Buffalo coach as an audible, quarterback Brady led New England to a 20-13 NFL victory over the Bills on Monday night and kept the defending Super Bowl champs on course for their second perfect regular season in nine years.

“That one is pretty unique,” Brady said of the Ryan audible.

Brady completed 20 of 39 passes for 277 yards, hitting James White for a 20-yard score that was the first touchdown of the running back’s career. White added a 6-yard run in the third quarter to give New England (10-0) the lead for good.

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LeSean McCoy ran 20 times for 82 yards for the Bills (5-5), who lost to Brady for the 25th time in 28 games.

New England lost another key player: Danny Amendola, who took over as the Patriots’ No. 1 receiver because of last week’s injury to Julian Edelman, caught nine passes for 117 yards before leaving with a knee injury of his own in the third quarter.