RENTON — Though injuries have been the Seahawks’ story of the week as they prepare for Sunday’s NFC West showdown with the 49ers at CenturyLink Field, there was some encouraging news Friday about two starters who had appeared unlikely to see action — safety Jamal Adams and running back Chris Carson.

Instead of being declared out or doubtful on the official status report Friday, both were listed as questionable, meaning the team views them to have a 50-50 shot to play. Adams also was listed as having practiced on a limited basis.

That helped somewhat offset the news that starting left cornerback Shaquill Griffin was declared out while battling a concussion and a hamstring injury, and that three other players are doubtful — running back Carlos Hyde (hamstring), guard Mike Iupati (back) and cornerback Ugo Amadi (hamstring).

“He worked today,” Carroll said of Adams, who was injured Sept. 27 against Dallas and then missed practices Wednesday and Thursday because of an illness. “He got some work today, so that’s a good sign. It’s a real good sign.”

Carroll, though, said he will give heavy consideration to Adams having had just one practice after missing more than a month.

“It’s a big concern,” Carroll said. “That’s a lot to ask. He’s worked out great in his conditioning work and all that. The fact that he had to miss a couple days here really kind of threw a wrench in the works for a smooth comeback. So we’ll have to see what happens on game time.”

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Carroll said Wednesday he anticipated Adams returning to practice that day. Instead, he showed up feeling ill and was sent home immediately as part of COVID-19 protocols. Adams was continually tested and allowed to return to the building Thursday.

“That’s the initial thing we do is to separate, make sure that we cover everything,” Carroll said. “He tested throughout, and he was fine. But that’s the first thing, first reaction is to separate and make sure that we make that move, and then look after him and get him through the testing process to ensure that he’s OK.”

Carson, meanwhile, suffered a sprained foot against Arizona, and an NFL Network report indicated he would miss some time.

Carson did not practice Friday, but Carroll said he will be evaluated Sunday to determine if he can play, calling him a game-time decision.

Also questionable are running back Travis Homer (knee), defensive end Benson Mayowa (ankle) and safety Ryan Neal (hamstring), though all three practiced Friday on a limited basis.

Even with a slight hope that Carson and Adams can play Sunday, the Seahawks are still looking at precarious situations in their backfield on offense and their back end on defense.

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Griffin will be replaced by Tre Flowers, with Seattle again unable to field its projected starting four in the secondary, something the team has done only twice this season.

Carroll also essentially ruled Amadi out, saying, “Ugo’s going to have to make a big comeback right here.”

So Seattle seems likely to have to go with yet another nickel — Amadi stepped into the role when Marquise Blair was lost for the season in the second game. That could be Linden Stephens, or the Seahawks could activate D.J. Reed off the non-football injury list.

“He is ready to play,” Carroll said of Reed, who returned to practice last week, indicating Seattle could add him to the roster by the Saturday deadline to play against the 49ers.

Carroll indicated that Neal will play, saying he “looks pretty good.”

And for all the talk all week of the running-back situation, it appears Hyde is the most injured of them all, with the questionable designations giving hope that Homer and Carson can play Sunday. Homer, who bruised a knee against Arizona, appears most likely given that he was able to practice some Friday. Hyde hurt his hamstring late in Sunday’s game.

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Carroll, though, said all three will be a game-time decision.

“Yeah, we’re going all the way to game time on all three guys and just see what happens then,” Carroll said. “We did not practice them this week, and that was just to give them every single day to have a chance to get back. So we’ll see them on the field on Sunday.”

Still, Seattle also will have to lean heavily on rookie DeeJay Dallas, who was the only running back healthy enough to practice Wednesday and Thursday.

“He’s had an excellent week,” Carroll said of Dallas, who had to play significantly late in the loss to Arizona in taking over Homer’s role as the third-down back. “He’s right in the middle of the plan, and he’s really jacked about the opportunity to carry the load if that would be what happens in this thing. So he had a good week. Later, as the week wore on, you know I was making sure we were taking care of him. I didn’t want to overwork him. He wanted to take every snap, and we didn’t let him do that. But he’s ready to play.”

With Iupati doubtful, Jordan Simmons seems in line to get his third consecutive start at left guard.

Carroll said Mayowa had a sore ankle coming out of the Arizona game, and the Seahawks wanted to rest him this week in practice.