Ouch, in every way possible on this day.

Arizona literally added injury to insult Sunday, knocking out Seattle’s top two tailbacks — Chris Carson and C.J. Prosise — to add to an already lengthy list of aches and pains for Seattle.

(Rich Boudet / The Seattle Times)

How Seattle can recover from those pains will be the story of the rest of the season.

As coach Pete Carroll revealed after the game, Carson and Prosise are done for the year while left tackle Duane Brown will miss the game against the 49ers next Sunday at the least because of knee surgery.

Suffice to say, this day turned out as bad as could have been imagined for Seattle.

On to some grades.

Quarterback

Russell Wilson looked to be off to another MVP-caliber day on the first drive. But it all went downhill from there for Wilson and the entire team. He finished with a season-low 169 yards passing. He also seemed unduly cautious to run early on — or maybe there was just no place to go.

Grade: C


Running back

Carson got off to a great start with 40 yards on eight carries in the first quarter.

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But his second-quarter injury changed everything, as did the Prosise injury shortly there after.

Travis Homer showed a nice burst at times, but he was held to minus-1 yard on four carries after getting 17 on his first carry. The Seahawks obviously are going to bring in a tailback or two next week — C.J. Anderson or maybe even Marshawn Lynch?

Grade: C


Wide receiver

Not a good day here at all, as Wilson often seemed to have no one open or was forced to throw into coverage.

The Seahawks finished with just three completions to receivers and none to rookie DK Metcalf, who was held without a reception for the first time in his career (and expect teams to scout what the Cardinals have done against him as he had one catch for 6 yards in two games against Arizona this year).

Malik Turner started as the third receiver in place of the suspended Josh Gordon, and you wondered heading into this game how much Gordon might be missed.

Seattle had just one completion to a receiver in the first half  — Turner on the first series.

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Tyler Lockett, meanwhile, had eight targets with just one catch. And David Moore appeared set to have a big play when he had a catch to covert momentarily a third-and-10 early in the third quarter. But he fumbled and Arizona recovered.

Grade: D


Tight end

Jacob Hollister was the team’s leading receiver with five receptions for 64 yards and had a 16-yarder to convert a third-and-11 early in the fourth quarter that seemed key at the time. Luke Willson didn’t have a target.

Grade: C


Offensive line

Duane Brown was really missed, as was Mike Iupati while he was out for much of the first half.

The Seahawks went with second-year player Jamarco Jones at left tackle in place of the injured Brown.

They then had to go with Ethan Pocic at left guard when Iupati left with a stinger late in the first quarter.

That led to some struggles in pass protection throughout, but particularly in the first half as Arizona had four of its five sacks by halftime.

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Iupati returned to play the second half — Carroll praised the fact that he “sucked it up” and came back to play — and the pass protection seemed to get a little better with his return. But by then it was too little, too late as Seattle never did  get a handle on Chandler Jones, who came into the game leading the league with 15 sacks and had four more, becoming the first player to ever sack Wilson four times in the same game.

Or as Carroll said of the pass protection: “We had a terrible time today.’’

Grade: D


Defensive line

There wasn’t a lot of pass rush, at least when Kyler Murray was in the game. Seattle had just two sacks, one by linebacker Bobby Wagner.

Ziggy Ansah “played a lot of football,’’ as Carroll put it. But he didn’t get a whole lot done with no sacks or QB hits.

Seattle obviously misses a healthy Jadeveon Clowney. But how much Seattle will get out of Clowney the rest of the year is hard to tell at this point.

Grade: C-


Linebackers

Mychal Kendricks returned to the starting lineup after missing the past two games with a hamstring injury. Cody Barton filled in for a series early before Kendricks returned.

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Seattle again used its dime package with Shaquem Griffin as an edge rusher throughout the game. Griffin helped blow up an early third-down play with a big rush off the edge that forced Murray to scramble.

But highlights everywhere were few.

Grade: C-


Secondary

Lano Hill got the start in place of Quandre Diggs and got outrun by Kenyan Drake on the 80-yard touchdown run that immediately got Arizona back in the game.

It’s unclear if Diggs will make it back next week, but Seattle has to hope so.

Ugo Amadi played the nickel and Marquise Blair was used in dime packages.

Amadi helped stop a third-and-three play early in the second quarter when he muddied up a receiver screen pass that Wagner was able to make the tackle on.

Grade: D-


Special teams

Michael Dickson punted well — he had a long of 63 and a perfectly placed ball that was downed at the 1 thanks to a heady play by Blair — and Jason Myers kicked well (a 51-yarder into the tough end zone). So there was that.

Grade: B