ROTTERDAM, Netherlands (AP) — Top-seeded Daniil Medvedev’s 12 aces weren’t enough as the Australian Open runner-up lost 7-6 (4), 6-4 to Dusan Lajovic in the first round of the ABN AMRO World Tennis Tournament on Wednesday.

It wasn’t the day’s only upset in Rotterdam, with third-seeded Alexander Zverev also losing.

Medvedev had 25 unforced errors against Lajovic’s 12, along with eight double-faults, and he broke his racket in frustration. It was the the third-ranked Russian first match since his straight-set loss to Novak Djokovic in the Australian Open final.

“I think I was very focused the whole match,” Lajovic said. “This was the key today, not to make the little mistakes.”

The 30-year-old Serbian player faces Borna Coric of Croatia in the second round.

Alexander Bublik beat Zverev 7-5, 6-3 to set up a second-round meeting with Tommy Paul. Zverev, coming off a quarterfinal loss to Djokovic in Australia, went a break up in each set against Bublik but each time was then broken twice himself.

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Three-time Grand Slam champion Andy Murray’s tournament run ended in a second-round loss to fourth-seeded Andrey Rublev, who won 7-5, 6-2. Murray hasn’t got past the second round of an ATP event since reaching the third-round in Cincinnati in August.

No seeded players remain in the top half of the Rotterdam draw after Alejandro Davidovich Fokina knocked out fifth-seeded Roberto Bautista Agut 6-2, 7-6 (3) in an all-Spanish match. Medvedev, Zverev and Felix Auger-Aliassime were all in that half of the draw but none reached the second round.

Sixth-seeded David Goffin needed just over an hour to beat Jan-Lennard Struff 6-4, 6-0. He’ll meet qualifier Jeremy Chardy in the second round.

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