Seattle falls at home to the Rockies, 6-3, ending the Mariners’ four-game winning streak. Jean Segura left the game with a right ankle injury while Nelson Cruz left after being hit in the left hand with a pitch.

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Hit with two more injuries Thursday afternoon — this to two of his most productive hitters — Mariners manager Scott Servais was trying to present an optimistic front.

“I do believe in our guys, and they know where we’re at,” he said. “We’re through feeling sorry for ourselves. We’re through that. That’s behind us.”

The Mariners’ feel-good finish in May turned into potential nightmare start to June when Jean Segura (ankle) and Nelson Cruz (hand) were injured during a 6-3 loss to the Colorado Rockies before a crowd of 21,536 at Safeco Field.

Servais had no specific updates on the injuries in the moments after game. He said both players were still being evaluated by doctors, and the team expects to know more Friday.

“We’ve dealt with (injuries) all year, and we’ll deal with this if we lose the guys,” Servais said. “But I’m hopeful that it is going to be a day-to-day thing with both of those guys. We’ll just have to wait and see.”

Cruz was hit in the left hand by a high fastball from Rockies starter Kyle Freeland in the third inning. After getting checked by a team trainer, Cruz remained in the game for the rest of the inning but was lifted in favor of pinch-hitter in the fifth.

“We’re hopeful that it’s not a broken bone or anything, but we don’t know,” Servais said.

Segura had to be helped off the field with the right ankle injury after his hard slide into second base during the fourth inning. On the play, Danny Valencia hit a sacrifice fly to left field, scoring Ben Gamel from third base. Segura tagged up from first base and was tagged out on a late slide at second, twisting his ankle in the process.

Segura had entered Thursday’s game leading the team in batting average (. 344), runs (29) and on-base percentage (. 392).

“I’m hopeful that (Segura) is not out for an extended period of time; we certainly need him,” Servais said.

Neither Cruz nor Segura were available for comment after the game.

The loss ended a four-game winning streak for the Mariners (25-30), who got another poor start from right-hander Yovani Gallardo (2-6).

Gallardo was chased after just three innings, in which he allowed five earned runs, with three walks, two strikeouts and two home runs allowed.

Gallardo said he feels fine physically. This, he said, is the best he’s felt in the past two or three years. His results, simply put, cannot be tolerated forever.

“It’s just frustrating. It’s very frustrating for me,” he said. “It’s one of those things I prepare myself each and every start, go out there and give the team an opportunity, a chance to win. When something like that happens, it’s tough. I wish I had a better answer for it.”

For a starting rotation as beat up as the Mariners’ is, the club needs more from a healthy veteran like Gallardo.

“He’s frustrated by it, and we’re frustrated by it,” Servais said.

A bright spot for the Mariners was right-hander Casey Lawrence, who relieved Gallardo and threw five solid innings of relief, allowing one run on three hits with nine strikeouts.

“I can’t say enough about the job Casey Lawrence did today,” Servais said. “It says a lot for him and his character.”

The Rockies took a 4-0 lead in the second inning.

Guillermo Heredia hit a line-drive home run to left, his fourth of the season, to cut the Mariners’ deficit to 4-1 in the second. Arenado answered with a solo shot to push the Rockies’ lead to 5-1.

Valencia’s sac fly got the M’s within 5-2, and Boog Powell — Cruz’s replacement — added an RBI single to cut the lead to 6-3, but Seattle couldn’t break through against Freeland (6-3).

“That was not an easy win for the Rockies,” Servais said. “We had all kinds of traffic out there; we just couldn’t quite get the big hit to get us within one or tie it up. But really good effort by our guys. We continued to play really good baseball, and hopefully it leads into a good weekend for us.”