SAN FRANCISCO (5-9) at ARIZONA (8-6)
Saturday, 4:30 p.m. ET, Amazon Prime Video
OPENING LINE – Cardinals by 3
RECORD VS. SPREAD – 49ers 5-9, Cardinals 7-7
SERIES RECORD – 49ers lead series 31-27
LAST MEETING – Cardinals beat 49ers 24-20, Sept. 13, 2020 in San Francisco
LAST WEEK – 49ers lost to Cowboys 41-33; Cardinals beat Eagles 33-26
AP PRO32 RANKING – 49ers No. 25, Cardinals No. 14
49ERS OFFENSE – OVERALL (13), RUSH (17), PASS (10).
49ERS DEFENSE – OVERALL (5), RUSH (8), PASS (4).
CARDINALS OFFENSE – OVERALL (3), RUSH (4), PASS (15).
CARDINALS DEFENSE – OVERALL (13), RUSH (17), PASS (12).
STREAKS, STATS AND NOTES — Arizona is trying for its fifth season sweep over San Francisco in the past six seasons. … The game will be the first to air on a national level exclusively on Amazon Prime Video, Twitch and Amazon’s other services. The game will also be broadcast in Arizona’s and San Francisco’s home markets. … The Niners are playing a road game at their temporary home in Arizona after being forced out of their home stadium because of coronavirus rules. San Francisco lost its two home games at State Farm Stadium. … The 49ers became the second team in the past 13 seasons to finish with a losing record the season after losing the Super Bowl. Carolina went 6-10 in 2016. … San Francisco has committed at least two turnovers in eight straight games for the first time since 2008. The last time the Niners had a longer streak in a single season came in 1978 when they did it in the first 11 games. … C.J. Beathard will make his first start at QB for the 49ers since 2018 with Jimmy Garoppolo and Nick Mullens injured. Beathard lost nine of 10 starts in 2017-18 and has a 77.2 career passer rating. … WR Brandon Aiyuk’s 59 catches are the second most for a San Francisco rookie, and his 733 yards receiving are third best. … The 49ers have gone four straight games without scoring on the opening drive, matching the longest streak in four seasons under Kyle Shanahan. … San Francisco DL Arik Armstead had two sacks last week for the first time since Nov. 24, 2019. He hadn’t had a sack this season since a half-sack in Week 4 vs. the Eagles. … The Niners have allowed a league-low 17 drives of at least 10 plays. … The Cardinals have played on a Monday, Thursday, Saturday and Sunday this season for just the second time in franchise history. The other instance was 2016. … The Cardinals have won their past two games and are alone in the No. 7 and final spot in the NFC playoff race. Arizona is trying to make the postseason for the first time since 2015. The Cardinals can clinch a playoff berth if they beat the 49ers and the Chicago Bears lose or tie against the Jacksonville Jaguars this weekend. … Cardinals LB Haason Reddick has five forced fumbles in his past two games. He’s the first player to do that since Pittsburgh’s James Harrison in 2007. … WR DeAndre Hopkins has 103 catches for 1,324 yards in his first season with Arizona. Hopkins is first in the NFL in receiving yards and second in catches. He’s also caught six touchdown passes. … Arizona QB Kyler Murray threw for a career-high 406 yards in last week’s win over the Eagles. … Fantasy tip: The Cardinals’ defense might be a good play this week considering it’s coming off a few solid performances and going against a 49ers team using a third-string QB.
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