Police say it appears the driver of the Shuttle Express van suffered some sort of medical emergency before jumping a curb and hitting four pedestrians in downtown Seattle.

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A 28-year-old man injured when a shuttle van jumped a curb in downtown Seattle has been upgraded from critical to serious condition, Harborview Medical Center said Friday morning.

Three other people injured in the Thursday morning crash — two women, ages 29 and 39, and a 52-year-old man — have been discharged from the hospital.

The four pedestrians were injured when the Shuttle Express van jumped the curb near Fifth Avenue and Pine Street and struck a building just before noon. Police said it appears the Shuttle Express driver suffered some sort of medical emergency and lost control of the van.

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The driver as well as another person who was hit by flying glass were also hospitalized, but their conditions were not immediately known.

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A Shuttle Express supervisor on Friday declined to identify the driver and said the company would not have any comment on the crash.

“I’m a supervisor and I have no comment and neither does anyone else,” she said. “And we won’t have any comment at any point.”