The Institute for Systems Biology and Providence Health & Services have agreed to a new affiliation aimed at expanding personalized medicine through joint research and clinical care.

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The Institute for Systems Biology (ISB), a Seattle biomedical research firm, and Providence Health & Services, the giant nonprofit Catholic health-care system, have agreed to a new affiliation aimed at expanding personalized medicine through joint research and clinical care.

As part of the venture, announced Monday, Dr. Leroy “Lee” Hood, who is president of ISB, has been named senior vice president and chief science officer of Providence Health & Services.

“This is an exciting moment for our patients,” Dr. Rod Hochman, president and chief executive of Providence, said in a statement. “With Lee’s visionary leadership, ISB has transformed the global understanding of human diseases and pioneered the emerging sector of scientific wellness.”

Providence and ISB plan a number of joint research projects aimed at identifying the earliest markers of disease and focusing on data-driven, scientific solutions. The affiliation will allow ISB to expand research capacity and to collaborate with Providence clinicians and scientists using data from the more than 3.3 million patients served by the hospital system.

ISB enters the new affiliation through Western HealthConnect, an entity set up by Providence that allows the hospital system to retain its Catholic identity and practices while allowing companies under its umbrella to retain secular practices.

ISB will remain a separate legal entity with its own brand and identity and a separate board of directors, officials said. It will set its own research agenda and oversee its own daily management and operations, officials said.

ISB was formed in 2000 by Hood, a systems biologist; Alan Aderem, an immunologist; and Ruedi Aebersold, a protein chemist. Providence Health & Services provides care through 34 hospitals, 600 clinics and other services in Alaska, California, Montana, Oregon and Washington.