It's unclear what led to the crash between a Metro Transit bus and vehicle near the intersection of Broadway and East Denny Way around 5 p.m. Tuesday.

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Three men have been hospitalized after a car crashed into a Metro Transit bus on Capitol Hill Tuesday evening, authorities said.

One man is suffering life-threatening injuries after the vehicle rear-ended the bus near the intersection of Broadway and East Denny Way shortly before 5 p.m., Seattle police and fire authorities said. Medics evaluated four other people with non-life threatening injuries, fire department spokesperson Corey Orvold said.

Medics transported the three men, including the person with the most significant injuries, to Harborview Medical Center, Orvold said. They were all in the vehicle, she said.

The other two people, who were riding the bus at the time of the crash, denied medical transport, Orvold said. Medics were in the area for at least an hour after the crash, providing emergency medical care, according to police and fire authorities.

In a statement released shortly before 6 p.m., Seattle police said traffic investigators were trying to determine what led to the crash.

The statement advises commuters take alternate routes.

No other details were immediately available.