The most stunning recent global event was the historic meeting of Pope Francis with Shiite Ayatollah Ali al-Sistani in a small, bare room in the holy city of Najaf, Iraq.

I say that not just because of the pope’s astonishing bravery in attempting to protect the remnants of Iraq’s ancient Christian sects, whose numbers have dwindled from around 1.5 million to 250,000, under attacks from ISIS and other violent Islamist extremists since the 2003 U.S. invasion. At age 84, in the time of COVID-19, the pope’s journey to Iraq was not for the faint hearted.

Nor do I say it only because the reclusive, ailing 94-year-old Sistani, perhaps the most revered Shiite cleric in the world, stood to greet the pope and joined him in condemning extremism.

No, this trip symbolized something much more significant, at a time when the world is convulsed by xenophobic nationalism, ugly strains of populism and deep cracks within democratic political systems. It was a desperate last plea by global religious moderates for justice and peace.

Both these religious leaders have promoted the rights of oppressed religious and ethnic groups and social justice for poor people, along with democratic political rule. But they have been challenged by hard-liners within their own religion and sects and by populist, authoritarian politicians. Their joint appearance was a poignant plea — perhaps a last stand — for values that are under increasing global threat.

While Shiites comprise only around 15% of all Muslims, the vast majority of whom are Sunnis (they differ over the proper succession to the prophet Muhammed), Iran and Iraq are predominantly Shiite.

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And Sistani is the preeminent Shiite ayatollah, leader of a school of religious thought that opposes direct involvement of clerics in political leadership. Thus he opposes the rule by clerics practiced in Shiite Iran since the 1979 Islamic revolution — and has endorsed constitutional elections in Iraq.

I was in Iraq in 2005 when the first national elections were held when posters all over Baghdad featured photos of the ayatollah telling Iraqis, especially his Shiite followers, to go to the polls. But unlike, say, the Muslim Brotherhood in Iraq, he supported subsequent elections. He has also supported youthful Iraqi demonstrators protesting corruption in government, including within Shiite political parties.

And Sistani, along with his religious establishment in Najaf, urged his followers to fight ISIS and protect Christians from persecution. He has also urged Shiite militiamen who fought ISIS to join the government or return home.

So when Sistani reaffirmed the right of Iraq’s “Christian citizens to live like all other Iraqis in safety and with their full constitutional rights” this was not just pablum.

A former Jesuit, Francis has campaigned all over the world for the poor and the marginalized, and even once washed the feet of Muslim asylum seekers. He has criticized the growth of nationalist populism in Europe, and warned that it could lead to a new Hitler. And he called former President Donald Trump “not Christian” for his anti-migrant rhetoric. The one time he met Trump he gave him a treatise on climate change.

The pope, too, has been criticized by religious conservatives. And his campaign to convince the dwindling Iraqi Christian community to remain is probably too late.

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The current Iraqi government is trying very hard to reign in violent militias, mostly sponsored by Iran, that still frighten Christians. But the clerics’ joint denunciation of religious fanaticism may not convince.

And yet, the sight of these two world famous clerics endorsing pluralism is still immensely moving — and also warning. When Sistani dies, Iran will try to exert more influence over Iraqi Shiites. And Pope Francis’ Vatican campaign for the poor may or may not outlast his papacy after he dies.

They have set down the markers, and tried their best in Najaf. Now it’s up to us.