Macau shut SJM Holdings’ Grand Lisboa, the first closure of a flagship gaming venue in more than two years, as the city struggles to contain its worst-ever virus outbreak.

The shutdown started Tuesday and is expected to last until July 11, and comes after authorities found 13 infections linked to the gaming resort. Officials have also locked down one floor of the “Shoppes at Four Seasons,” a shopping center at Sands China’s Plaza Macao, after another cluster was found there, though the rest of the resort remains open for now.

It’s the first time Macau has shut a casino owned by the city’s six licensed gaming operators since an unprecedented 15-day shutdown of all venues in February 2020, and follows the closure of bars to cinemas and public venues late last month. The city is conducting multiple rounds of mass testing to try to weed out hidden chains of community transmission, with authorities locking down buildings across the city when cases are found in more than one apartment.

Macau reported 89 local infections for Monday, plus two imported cases, bringing the total for the outbreak that started on June 18 to 951.

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While small by global standards, the flare-up follows months of virus-free life for Macau and raises the specter of more disruptions to come. It also deals a substantial economic blow to the city that was already grappling with a dearth of tourists and slumping gaming revenue as mainland China’s COVID Zero policies discourage travel to the enclave, with casinos burning through millions of dollars each day they stay open.

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Most casinos have enough liquidity to survive between nine months and two years, JPMorgan Chase & Co. estimates. A Bloomberg Intelligence gauge of casino stocks extended losses and is down 17% this year.

Macau remains quarantine-free for travelers from low-risk areas in mainland China, the largest source of its tourism, while a 10-day quarantine is required for those who enter from Hong Kong, Taiwan, Portugal and some high-risk mainland regions. It is otherwise shut to the rest of the world.

The neighboring mainland city of Zhuhai tightened its border restrictions for visitors from Macau, requiring seven days of quarantine at designated facilities and another seven days of self-health monitoring. Before the outbreak, arrivals didn’t have to undergo any isolation.

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Bloomberg’s Felix Tam contributed to this report.