The Los Angeles Police Department confirmed that Garry Shandling, known for “The Larry Sanders Show” and “It’s Garry Shandling’s Show” on cable television, was transferred by ambulance to a local hospital, where he died.

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Garry Shandling, the pioneering cable TV star and writer whose turn as a self-doubting talk-show host on HBO’s “The Larry Sanders Show” during the 1990s helped redefine the television sitcom, has died. He was 66.

The Chicago-born Shandling died Thursday in Los Angeles of a heart attack, spokesman Alan Nierob said.

Shandling was among a generation of comics who helped revolutionize TV comedy by casting aside the setup-punchline mechanics of the traditional network sitcom and exploring characterization more deeply. Like his contemporary David Letterman, Shandling had little patience for show business conventions, which he found worthy of ridicule. Unlike Letterman, he never earned the brass ring of his own network talk show, even though he was a frequent guest host on “The Tonight Show” and was at one time, along with Letterman and Joan Rivers, a leading contender to replace Johnny Carson, who retired in 1992. That job ultimately went to Jay Leno.

Instead, Shandling reached his greatest career pinnacle as Larry Sanders, a host of a fictional talk show who was caught in an awkward, passive-aggressive dance with everyone in his sphere, including his on-air sidekick Hank “Hey Now” Kingsley (Jeffrey Tambor). “Larry Sanders,” which aired on HBO from 1992 to 1998, pushed the boundaries by featuring real celebrities in sometimes less-than-flattering cameos (often discussing real projects), having Shandling directly address the audience and refer not-so-subtly to his own problems and — especially controversial at the time — doing away with a laugh track.

Such features are now commonplace in sitcoms ranging from “The Office” to “30 Rock” to “Modern Family,” but they were groundbreaking at the time, with “Larry Sanders” winning numerous awards, including three Primetime Emmys.

Shandling died after being rushed to the hospital after an unspecified medical emergency, according to the Los Angeles Police Department, which said it would investigate the cause of his death. No further details were immediately available.

Shandling never married and appeared to have no close survivors.

Comics who felt his influence took to social media to pay their respects.

“Garry Shandling was as kind and generous as he was funny and that is saying a lot,” Jimmy Kimmel tweeted. Albert Brooks wrote: “Brilliantly funny and such a great guy. He will be so missed.”

“Garry would see the ridiculousness of me being asked to sum up his life five minutes after being told of his passing. It is a perfect, ridiculous Larry Sanders moment,” director Judd Apatow said in a statement. “I can imagine how Hank would handle it but I just don’t know how to sum up someone I loved so much who taught me everything I know and was always so kind to me. I am just too sad. Maybe tomorrow I will do better.”

“Working with him was one of the great privileges of my career,” said costar Rip Torn, who played Sanders’ blustery producer, Artie. “He was a comic talent of immense originality who enthusiastically encouraged and responded to the originality of others.”

HBO said in a statement: “Garry ushered in the modern period of original programming at HBO with his brilliant masterpiece, ‘The Larry Sanders Show.’ All of us at HBO have a special place in our hearts for him not only for his enormous talent but for his kindness and decency. We will miss him terribly.”

He booked a coveted spot on Johnny Carson’s “Tonight Show” in 1981, and became a regular guest on the show. Carson, whose favor was highly sought after by young comics, tapped him as a permanent guest host.

By 1986, he had created his own sitcom for Showtime, “It’s Garry Shandling’s Show.” The series, co-created by Alan Zweibel, ran until 1990.

More recently, Shandling joined Jerry Seinfeld on his Web series “Comedians In Cars Getting Coffee” in an episode with the eerily foreboding title, “It’s Great That Garry Shandling Is Still Alive.”

In the episode, the comedy pals toured their old stomping grounds of the Comedy Store and talked about their career paths. During the drive, Shandling mentioned he had a hyperparathyroid gland that was undiagnosed because, as Shandling put it, “the symptoms mirror the exact same symptoms an older Jewish man would have. Which is, you know, lethargic, you get puffy, you get heavy, you kind of feel like you want a divorce but you’re thinking you’re not married.”

The pair also chatted about death, particularly those of fellow comedians Robin Williams and David Brenner, and the legacy of their work. Shandling said material “is purely a vehicle for you to express your spirit. And your soul, and your being” before expressing in his droll way what he’d want his end to be like.

“What I want at my funeral is an actual boxing referee to do a count. And at 5 just wave it off and say, ‘He’s not getting up,’” Shandling said.