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CAIRO (AP) — Clashes between Egyptian security forces and Muslim Brotherhood supporters killed at least six people on Friday, after demonstrations in Cairo at the start of a major religious holiday weekend descended into violence.

It was the deadliest toll at Islamist protests for months in the capital, and came as part of a violent crackdown on the Brotherhood, which authorities have banned and labelled a terrorist organization.

The fighting erupted when hundreds of Brotherhood supporters staged a march in the Talibiya neighborhood of Giza, which is part of greater Cairo, after morning prayers following the end of the holy month of Ramadan and the start of the major Muslim holiday, Eid al-Fitr.

Skirmishes broke out between marchers on one side and local residents and police on the other. The violence quickly escalated with live ammunition and shotguns, a security official said, speaking on condition of anonymity in line with regulations.

Brotherhood supporters took to social media to accuse security forces of firing at peaceful protesters, while the Interior Ministry and police officials said in a statement that they were fired upon by armed protesters.

A video circulating on social media showed a crowd of young demonstrators in a standoff with police, shooting fireworks in their direction and burning flares before fleeing as explosions are heard. It could not be independently verified but it corresponded to events reported by The Associated Press.

The ministry said in a statement that five demonstrators were killed in the Talibiya clashes, and one in the nearby town of Nahia, an Islamist stronghold where another group of protesters clashed with police. A total of 15 people were wounded.

It said that police had gained control of the Talibiya area, which is located near the main road that leads to the famed Giza pyramids, and had arrested 15 Brotherhood supporters.

The ministry said the man killed in Nahia was a known Brotherhood supporter and demonstrator who had previously been detained by police. The town is fervently anti-government and is considered a no-go zone for security forces.

Political violence has increased in Egypt, two years after Islamist President Mohammed Morsi was ousted by the military, following mass protests against his rule. After Morsi’s ouster, his successor and current President Abdel-Fattah el-Sissi launched a sweeping crackdown on dissent that has killed hundreds and jailed thousands.

Attacks on security personnel and officials also intensified after Morsi’s ouster, and outlawed demonstrations continue regularly in poor suburbs and villages.

Egyptian authorities blame most attacks on Morsi’s Muslim Brotherhood group, which denies using violence. But Brotherhood ranks have grown divided recently on whether to use force to confront the government in response to the nearly 2-year-old crackdown against them.

Egypt also faces threats from multiple insurgent factions, including the Islamic State affiliate in the Sinai Peninsula, which the military says killed at least 17 soldiers in a July 1 assault there. Officials from several branches of Egypt’s security forces previously told the AP that that attack killed dozens more.

In late June, Prosecutor General Hisham Barakat was assassinated in Cairo by a car bomb — an attack for which the Islamic State affiliate also claimed responsibility.

Last week, another car bomb ripped into the Italian Consulate in Cairo, destroying a section of the historic building in a powerful blast that was the most significant attack yet on foreign interests in Egypt.