Chan rarely talks publicly about how her personal story has influenced the giving by her and her husband, Facebook co-founder Mark Zuckerberg.

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Priscilla Chan remembers seeing blood all over the boy’s face, a sign he had gotten jumped in his own neighborhood. For the first time, just looking at someone else hurt.

Chan, then a Harvard student and now a Bay Area philanthropist, pediatrician, mother and wife of Facebook co-founder Mark Zuckerberg, was mentoring the child in an after-school program meant to quell gang violence in Boston’s Dorchester neighborhood. Yet stellar tutoring and field trips to football fields and skating rinks couldn’t cure the student’s woes.

“I realized that my homework help was going to completely be futile if these kids couldn’t be healthy, safe and happy in the place that they lived,” a teary-eyed Chan told the San Jose Mercury News in a rare interview. “That really drives a lot of what I decided to do in my life and career.”

Priscilla Chan

Education: Bachelor’s in biology, Harvard; M.D., University of California at San Francisco

Family: With husband Mark Zuckeberg, parents of daughter Max

Currently: Philanthropist; founder and CEO of The Primary School in East Palo Alto

Source: San Jose Mercury News

Chan is the private face of the philanthropic couple, working quietly behind the scenes. While Zuckerberg is a prominent player among Silicon Valley’s tech elite and his life story is widely known, Chan rarely talks publicly about how her personal story has helped shape the couple’s multimillion-dollar donations to schools and hospitals.

Wealth and power used to be foreign to Chan, the child of immigrant parents who fled Vietnam on refugee boats in the 1970s and never went to college.

Now Chan and her husband have invested hundreds of millions of dollars to improve education and health care for children, including in the Bay Area. They have vowed to donate 99 percent of their Facebook shares — worth more than $45 billion — to charitable causes.

And Chan, a former teacher, has taken it a step further. In October she announced she was founding and would be CEO of The Primary School, which will link health care and education for 50 Bay Area families when it opens this fall. Teaming up with the Ravenswood Family Health Center, the free school, serving students from pre-K to eighth grade, will provide services from mental health to prenatal care for students and their families. The private school is funded by Chan and Zuckerberg, but they have not disclosed how much they are pumping into the effort.

Suddenly Chan, a San Francisco General pediatrician who has largely shied away from public attention, found herself in the spotlight as the doctor being the catalyst of change for some of the Bay Area’s most disadvantaged children.

While Chan was growing up in Quincy, Mass., her family stressed the importance of school and hard work as the keys to a life better than the one the Chinese-Vietnamese refugees left behind.

But even in a place nicknamed the “Birthplace of the American dream,” Chan knew her upbringing was different from those of other children raised in the Irish Catholic town.

“My identity, I felt, was so distinct. I felt very much like an outsider. My family didn’t have the same rituals that everyone else seemed to have,” she said.

Her Cantonese-speaking grandparents raised her and two younger sisters while her parents, Dennis and Yvonne, worked long hours at a Chinese restaurant and other jobs.

And while her parents never attended college, they wanted their daughters to do better, though it was an abstract idea rather than a road map filled with specific colleges and test scores.

At Quincy High School, Chan’s teachers helped fill in the gaps.

Peter Swanson, her science teacher and tennis coach, remembered Chan asking if joining the tennis team could help get her into a college like Harvard. It wouldn’t hurt, he told her, along with straight A’s, advanced courses and high SAT scores. Voted “class genius,” Chan wasn’t a naturally gifted tennis player but worked hard to improve on the court.

She graduated at the top of her class in 2003.

At Harvard, surrounded by brick buildings, libraries and bronze sculptures, Chan saw the wealth of opportunities an Ivy League education could bring.

But she felt out of place. Doubt crept into her mind, but so did the desire to give back.

“These opportunities for sure were not available to many of the people I grew up with,” Chan said.

So she went to the Phillips Brooks House Association, a student-run nonprofit at Harvard, and signed up for the Franklin Afterschool Enrichment program. Volunteers met at the front of Lamont Library, taking buses to the Franklin Hill and Franklin Field public-housing units in Dorchester, where they tutored and mentored children.

It was at Harvard that Chan met Zuckerberg while waiting in line for the bathroom at a fraternity party. The couple married in 2012 in the backyard of their Palo Alto home.

After earning her biology degree from Harvard in 2007, Chan spent a school year teaching fourth- and fifth-grade science at The Harker School, a private college-preparatory school in San Jose.

“Those kids were completely different than the kids that I taught in the after-school program,” said Chan, who will be the keynote speaker at Harker’s graduation this year. “But kids, in general, have common grounds and common foundations that they need to build.”

Inspired by working with kids in the after-school program and as a pediatrician, Chan started quietly working on The Primary School while she was a resident at the University of California at San Francisco. As part of the Pediatric Leadership for the Underserved program, residents had to complete a project, but Chan had her sights on a task that was far more ambitious — opening a new school.

“It was incredible what she pulled off. Being a resident and working that sort of arduous schedule is taxing in and of itself,” said Dr. Meg McNamara, a mentor in the program who worked with Chan.

In an office space filled with bursts of bright colors, The Primary School’s logo — a hand with a heart in its palm — jumps out. Incorporated into the logo are images representing five values: excellence, growth, courage, community and soul.

Chan, who gave birth to her first child — a daughter — in late 2015, knows education reform can’t wait.

“Before I had Max, I had all these experiences that gave me what I felt like was a strong empathy for how important it is for children to have all these opportunities and how much families want to invest and want the best for their kids,” Chan said. “But after I had Max, I feel that every day.”