The major stock indexes struck fresh lows for the year yesterday as a cautious forecast from Apple Computer unsettled investors, who are...

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NEW YORK — The major stock indexes struck fresh lows for the year yesterday as a cautious forecast from Apple Computer unsettled investors, who are growing uneasy about the economy despite signs of continued improvement in the labor market.

The Dow Jones industrial average and the Standard & Poor’s 500 sank to five-month lows, reflecting the market’s anxiety about interest rates and the economy.

The Dow slumped 125.18, or 1.20 percent, to 10,278.75. It was the Dow’s worst close since Nov. 3, when it finished at 10,137.05.

The broader indexes also fell. The Nasdaq composite index shed 27.66, or 1.40 percent, to 1,946.71. The last time it closed lower was on Oct. 26, when it ended at 1,928.79. The S&P 500 declined 11.74, or 1.00 percent, to 1,162.05; it has not closed lower since Nov. 4, when it stood at 1,161.67.

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Microsoft, one of the 30 Dow stocks, lost 20 cents a share to close at $24.84. Boeing, also a Dow stock, lost 51 cents to $58.16.

After a disappointing retail sales report for March, investors seemed intent on focusing on negative news, but with earnings season just barely under way, some analysts said it was too soon to assume the worst.

“We don’t think any kind of concrete opinion about earnings can be formed yet because we’re still in the early stages,” said Brian Belski, market strategist at Piper Jaffray. “We are in defensive, reactionary times, which longer term have traditionally provided good entry points.”

Analysts were struck by what many characterized as a shift in the market after Wednesday’s lower-than-expected retail sales results, which ignited fears of a slowdown in consumer spending, and in turn, corporate earnings.

The only thing that could ease those concerns could be upbeat forecasts for the rest of the year from market bellwethers reporting over the next few weeks. But an after-the-bell earnings miss by IBM cast doubt on the likelihood of that happening.

“You haven’t heard the phrase ‘economic slowdown’ in a while. There are real questions about the strength of the economy in the second half,” said Jay Suskind, head trader at Ryan Beck & Co. “Investors are wondering if these numbers are the best we’re going to see. It’s as if good news is bad and bad news is bad. The sentiment is one of fears and jitters, and no one wants to buy this market.”

Crude prices were volatile a day after flirting with a seven-week low. Light, sweet crude for May delivery slipped in early trading, but rebounded after falling below the $50 mark. Oil futures climbed 91 cents to settle at $51.13 per barrel on the New York Mercantile Exchange.

Treasurys were higher after the successful sale of inflation-indexed notes; the yield on the 10-year note slipped to 4.34 percent, down from 4.36 percent late Wednesday. The U.S. dollar strengthened against other major currencies; gold prices fell.

The number of Americans seeking unemployment benefits for the first time fell by 10,000 last week, a second straight week of improvement, according to the Labor Department. That brings the four-week moving average, designed to smooth out volatility, to 338,000.

Apple declined 9.2 percent, or $3.78, to $37.26, despite the fact that quarterly profits jumped more than sixfold thanks to its iPod music players.

General Motors plunged to a 12-year low after United Auto Workers officials indicated they were not willing to reopen a labor contract to negotiate lower health-care costs. The automaker lost 5.9 percent, or $1.67, to $26.66, making it the worst-performing stock on the Dow.

Among gainers, Kerr-McGee rose 6.7 percent, or $4.93, to $78.90, after the oil and gas company said its board had authorized a tender offer to buy back up to $4 billion of the company’s common stock at a price between $85 and $92 per share.

The company said it reached a settlement with billionaire financier Carl Icahn, certain affiliated funds and Jana Partners, who own 7.5 percent of Kerr-McGee collectively and were seeking election to the company’s board.