Amazon has signed a long-term lease for all the space in the 1260 Mercer building, just south of Interstate 5's Mercer Street ramps, said the building's landlord.

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Fast-growing Amazon.com is expanding into yet another South Lake Union office building.

Landlord The Blume Co. said Friday that Amazon has signed a long-term lease for all the space in its 1260 Mercer building, just south of Interstate 5’s Mercer Street ramps.

The 106,000-square-foot building’s last tenant, the Gates Foundation, moved into a new headquarters campus near Seattle Center earlier this year.

Amazon will occupy 1260 Mercer early in 2012, according to Blume and CBRE, the listing brokerage.

The online retailer’s growth is helping to drive down the office-vacancy rate in greater downtown.

In addition to its 1.7-million-square-foot headquarters complex — built for it by Vulcan Real Estate — Amazon also has leased a total of 640,000 square feet at the 1918 Eighth and 2201 Westlake office towers.

Earlier this week building-permit applications filed with the city confirmed Amazon also is leasing about 280,000 square feet at 28-story West Eighth.

Eric Pryne: 206-464-2231 or epryne@seattletimes.com