Coach: Jim Harbaugh
Last game: The 49ers beat the Packers on Sunday in their season opener, 34-28, behind the 412 passing yards of their third-year quarterback, Colin Kaepernick.
The early line: Seattle is favored by three points.
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Strengths: The 49ers are again a favorite to get to the Super Bowl due to the run-pass ability of Kaepernick, the receiving of free-agent signee Anquan Boldin, a veteran offensive line and a defense that ranked third in the NFL last season.
Weaknesses: The receiving corps was thought to be one of the team’s biggest question marks after an offseason injury to star Michael Crabtree. But Boldin had 208 yards receiving in the victory over Green Bay to allay those concerns. The secondary also had significant turnover in the offseason and is a work in progress.
Star players: Kaepernick has started only 11 games, but already is considered one of the best quarterbacks in the NFL, equipped with one of the strongest arms and superb running ability. Inside linebackers NaVorro Bowman and Patrick Willis are the heart and soul of the defense.
Seahawks’ key to success: While Kaepernick has shown he can pass, Seattle will still take its chances with trying to shut down San Francisco’s running game and turning him into a pocket passer. Seattle also will have to run much better than it did against Carolina to keep the ball out of Kaepernick’s hands.
By the numbers
11 Penalties committed by the 49ers on Sunday, tying their 2012 high.
13-3 Kaepernick’s career touchdown-to-interception ratio.
8-7 Seattle’s overall record against the 49ers at home.