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SAN FRANCISCO — First, tight end Vernon Davis went down with a concussion. Then it was standout rookie safety Eric Reid.

Perhaps more concerning for San Francisco than a lackluster 10-9 defeat to the Carolina Panthers on Sunday is the loss of a key player from each side of the ball along with a handful of other injuries as the reigning NFC champions head into the season’s stretch run 2½ games behind the Seahawks in the NFC West with two tough road games up next, too.

Drayton Florence intercepted a pass by Colin Kaepernick in the final minute to seal it as the Panthers snapped the 49ers’ five-game winning streak.

Coach Jim Harbaugh didn’t yet know much about how Davis and Reid were doing.

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Still, both players will be put through a concussion protocol involving several different steps and an evaluation once they become symptom-free.

The Niners (6-3) hit the road next week for New Orleans, then go to Washington.

“We’ll do what we do, bounce back, regroup, refit and reorganize and come back this week,” Harbaugh said.

Locker injures foot

NASHVILLE, Tenn. — Another season, another inexplicable loss by the Tennessee Titans to a previously winless team.

The Titans likely will be without quarterback Jake Locker Thursday against the Colts and perhaps beyond. The former Ferndale High and Washington star hurt his right foot in the second quarter at the end of an option keeper and left the stadium on crutches wearing a walking boot.

Locker said he will have more tests Monday to determine the extent of the damage but said he’s hoping it’s not a season-ending injury. Reports say the Titans said he suffered a Lisfranc injury, and surgery is a possibility.

“I can’t imagine in four days he’d able to play, as sore as he was,” Tennessee coach Mike Munchak said of Locker.

The Titans turned the ball over a season-high four times as Jacksonville got its first win this season, 29-27.


• Green Bay coach Mike McCarthy elevated Scott Tolzien to starting quarterback after a 27-13 loss to Philadelphia. Tolzien, who was on the Packers’ practice squad until last week, played most of Sunday’s game after starter Seneca Wallace injured his groin during Green Bay’s first possession. Tolzien finished 24 of 38 for 280 yards with one touchdown pass and two interceptions.

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