SAN FRANCISCO — The San Francisco 49ers find themselves in unfamiliar territory under third-year coach Jim Harbaugh: on a losing streak.

It’s pretty uncomfortable for all involved considering the rash of uncharacteristic penalties, a star player headed to rehab for an indefinite absence, and an offense that has produced 10 points the past two games.

Andrew Luck thoroughly outshined Colin Kaepernick in a matchup of Jim Harbaugh quarterbacks past and present, and the Indianapolis Colts beat the San Francisco 49ers 27-7 on Sunday.

“Not winning this game, not being in position to make plays and make it competitive, that was disappointing to all of us,” Harbaugh said. “You can question just about everything right now. We didn’t play well enough to win in enough areas, on enough downs.”

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San Francisco has a quick turnaround before a key division matchup at St. Louis on Thursday night — but the 49ers won’t have linebacker Aldon Smith, who is seeking treatment after his arrest Friday morning on suspicion of DUI and marijuana possession.

Smith apologized after the game to “everybody I let down,” while 49ers CEO Jed York defended the organization’s decision to let him play ahead of him leaving the team to get help this week.


Jake Locker, the former Husky, threw a 34-yard TD pass to rookie Justin Hunter with 15 seconds left and Tennessee rallied by San Diego 20-17.

“Honestly, once I threw it and saw them both jump to go up for it, it was so much higher than the guy guarding him, I started celebrating,” Locker said.

Locker completed seven passes to six receivers for 94 yards on the winning drive. The eighth overall draft pick in 2011 finished with 299 yards passing and also ran for 68 yards and another touchdown.

“That’s a huge game for him and this football team again,” Titans coach Mike Munchak said of Locker.