Game time: 10 a.m. (Pacific), Lucas Oil Stadium. TV: Ch. 13.

Coach: Chuck Pagano (5-3 in parts of two seasons with the Colts).

Record: 3-1. Last game: Won at Jacksonville, 37-3.

The series: Seattle is 4-6 against the Colts, and 4-4 since the franchise moved to Indianapolis in 1984. The Seahawks are 1-2 in games in Indianapolis with the victory, 31-3, in 1997.

The early line: The Seahawks by 2½ points.

Key players: The Colts are led by Andrew Luck, the one-time Stanford standout who was the No. 1 choice in the 2012 draft. After a fabulous rookie year, Luck has shown no signs of a drop-off, compiling a 91.9 quarterback rating this season with five touchdown passes against two interceptions. He also has used his legs to great effect, rushing for 126 yards and an average of 7.9 yards per carry. Luck’s favorite target is the ageless Reggie Wayne, who has 990 catches in 13 NFL seasons, including 22 for 300 yards this year. The Colts’ defense is led by linebacker Robert Mathis, who has 7.5 sacks, tied for the most in the league.

Indianapolis’ key to success: The Colts have quickly turned things around the past two seasons after drafting Luck and are 14-6 in regular-season games since he became the quarterback in 2012. The Colts do it with a style that isn’t flashy, but is effective, ranking fourth in the NFL in rushing at 149.5 yards per game, and fifth in fewest points allowed (12.8). Indy has outscored opponents this year 105-51, similar to Seattle’s 109-47.