SAN ANTONIO – Iowa State’s DeAndre Kane did exactly as coach Fred Hoiberg had instructed, driving for a layup that gave the Cyclones the lead. North Carolina never got a chance to answer because Roy Williams’ players didn’t do what he wanted.

With Williams jumping and gesturing for a timeout, the Tar Heels inbounded the ball to Nate Britt, who dribbled past midcourt as time expired in Iowa State’s 85-83 victory Sunday.

The Cyclones are in the Sweet 16 of the NCAA tournament for the first time since 2000.

As soon as officials explained the game was over, Williams — who collapsed his hands on his knees as Britt surged toward him — shook Hoiberg’s hand as North Carolina (24-10) began absorbing the heartbreaker.

“Let’s not anybody lay it on the officials or anything like that. We didn’t call the timeout with 1.6 seconds to play,” Williams said.

Kane had 24 points and 10 rebounds for the third-seeded Cyclones (28-7), who will play No. 7 seed Connecticut (28-8) on Friday at Madison Square Garden in New York.

Kane said Iowa State’s last possession called for him to attack the basket, unless North Carolina defenders swarmed him as he penetrated.

“But nobody helped, and I made an acrobatic shot and it went in,” Kane said.

Virginia 78, Memphis 60

RALEIGH, N.C. – Joe Harris, who is from Chelan, scored 16 points and top-seeded Virginia shot 56 percent to beat Memphis, earning its first trip to the NCAA tournament round of 16 since 1995.

Anthony Gill added 13 points for the Cavaliers (30-6), who shut down the eighth-seeded Tigers (24-10).

Virginia, guided by ex-Washington State coach Tony Bennett, plays fourth-seeded Michigan State (28-8) Friday in New York.