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WASHINGTON — After more than a decade of stalemate and threats, the clock starts Monday on the six-month initial phase of a deal that negotiators for Iran, the United States and five other world powers say could lead to a permanent agreement to defuse tensions over Iran’s nuclear program.

Beginning Monday, Iran agreed to take steps to curtail some aspects of its nuclear program in exchange for $7 billion in relief from economic sanctions that the U.S. and its allies have imposed on the Islamic republic.

The measures are intended to build confidence between the two sides that a permanent deal would be respected by both and won’t be used by the Iranians to get closer to building a nuclear weapon, as the United States has accused them of doing.

But reaching a permanent deal — and removing from the world’s problems the threat of a military strike against Iran — is not a certainty. Hard-liners in both countries oppose the interim deal, even as the Obama administration and supporters argue that it marks the first time Iran has agreed to limit its nuclear program.

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“It’s a huge step forward,” said Daryl Kimball, executive director of Arms Control Association, a policy institute in Washington that’s closely monitored the nuclear talks. “It’s not everything we want it to be, and it’s not everything the Iranians want it to be, but it’s far better than an unconstrained Iranian nuclear program.”

Starting Monday, according to the interim deal, President Hassan Rouhani’s government is expected to halt uranium enrichment above normal fuel grade, stop adding centrifuges at enrichment plants and end nuclear-related activities at the unfinished Arak heavy-water reactor. It’s agreed to submit to daily inspections from international experts.

The United States and other powers are expected to ease some sanctions and free up several billion dollars in frozen Iranian oil revenues on a staggered timetable.

Iran and the so-called P5-plus-one — U.N. Security Council permanent members the United States, France, Russia, China and the United Kingdom, plus Germany — took months to set forth the principles in the interim agreement, which they announced as a deal Nov. 24. It took several more weeks to work out the logistics of how the deal would be executed. The next phase will be even more complicated.

This delicate first stage, analysts said, gives the international community an unprecedented window into Iran’s long-shrouded nuclear activities and offers Rouhani’s relatively moderate administration a chance to prove that there are benefits to moving Iran away from its status as a pariah state.

Mistrust is so high between Iran and the West that the compromise was a symbiotic “mutual-hostage arrangement,” as one observer put it. Each side has the ability to speed up or slow down its progress on benchmarks based on its perception of how well the opposite side is fulfilling its end of the bargain.

But long-standing mutual mistrust, analysts say, isn’t the biggest stumbling block to this or future phases of a nuclear deal.

In the United States, members of Congress who oppose any such agreement with Iran are trying to push through legislation that would add new sanctions, effectively violating the Obama administration’s pledge in the interim deal to refrain from imposing new nuclear-related sanctions for the next six months.

Such a reneging could embolden Rouhani’s hard-line detractors in Iran who have criticized the recently installed president’s efforts to ease Iran back into the international fold.

Reports say that a majority of the Senate is in favor of a new sanctions bill introduced by Sens. Robert Menendez, D-N.J., Mark Kirk, R-Ill., and Chuck Schumer, D-N.Y., that includes language the administration argues would torpedo any chance of a long-term deal by imposing unrealistic terms.

As noted by the journalist Ali Gharib in a blog post for Washington Monthly, the bill contains a “poison pill” with a demand for a halt to all uranium enrichment, a condition the Iranians repeatedly have rejected.

The administration is pushing Democratic lawmakers to oppose the bill, saying that the opposition to the deal doesn’t make sense because the absence of a deal leaves two options: Accept the potential for a nuclear-armed Iran or prepare for military confrontation with Iran over its program.

Already, as the Gharib blog noted, Iranian Foreign Minister Javad Zarif has warned that new sanctions would mean “the entire deal is dead.” And there’s concern, analysts say, of tit-for-tat legislation from Iran that would boost enrichment up to 60 percent, even closer to weapons-grade levels.

“The flies in the ointment don’t have to do with irreconcilable differences, but with elements on both sides that are intent on torpedoing the process,” said Paul Pillar, an adjunct senior fellow at Georgetown University’s Center For Security Studies, who spent nearly three decades in intelligence work focused on the Middle East and Persian Gulf.

Alireza Nader, a senior policy analyst at the Washington-based RAND research institute and author of “Iran After the Bomb,” suggested the West should capitalize on this rare opening from a notoriously closed off and hostile Shiite Muslim theocracy. Rouhani’s ability to deliver on the nuclear deal, Nader said, will have a ripple effect on his whole set of overtures to the West.

He added that even Iran’s highest power, the Supreme Leader Ayatollah Ali Khamenei, has admonished Rouhani’s critics in public statements that describe the nuclear negotiations as in the government’s best interests.

Nader warned, however, that nascent support from the religious authorities isn’t guaranteed, especially if the United States brings new sanctions in violation of the agreement.

“He promised the Iranian people he’d improve their standard of living, decrease Iran’s political isolation and ease repression,” Nader said. “A lot of that depends on what happens with the nuclear deal. If he’s unable to succeed with negotiations, then chances of economic and political liberalization go down.”

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