Patient Zero in the Ebola outbreak, researchers suspect, was a 2-year-old boy who died Dec. 6, a few days after falling ill in a village in Guéckédou, in southeastern Guinea. Bordering Sierra Leone and Liberia, Guéckédou is at the intersection of three nations, where the disease found an easy entry point to the region.
A week later, it killed the boy’s mother, then his 3-year-old sister, then his grandmother. All had fever, vomiting and diarrhea, but no one knew what had sickened them.
Two mourners at the grandmother’s funeral took the virus home to their village. A health worker carried it to still another, where he died, as did his doctor. They both infected relatives from other towns. By the time Ebola was recognized, in March, dozens of people had died in eight Guinean communities, and suspected cases were popping up in Liberia and Sierra Leone — three of the world’s poorest countries, recovering from years of political dysfunction and civil war.
In Guéckédou, where it all began, “the feeling was fright,” said Dr. Kalissa N’fansoumane, the hospital director. He had to persuade employees to come to work.
- Anonymous donor pays off landslide victim's $360K mortgage
- Man arrested for carrying golf club sues city, Seattle cop
- 'Hero' teacher tackles shooter at North Thurston High School
- Jernard Jarreau leaving Washington
- Seattle-to-suburb commuters prefer urban lifestyle
Most Read Stories
On March 31, Doctors Without Borders, which has intervened in many Ebola outbreaks, called this one “unprecedented,” and warned that the disease had erupted in so many locations that fighting it would be enormously difficult.
Now, with at least 1,779 cases, including at least 961 deaths, and a cluster in Nigeria, the outbreak is out of control and getting worse. Not only is it the largest ever, but it also seems likely to surpass all two dozen previous known Ebola outbreaks combined. Epidemiologists predict it will take months to control, perhaps many months, and a spokesman for the World Health Organization (WHO) said thousands more health workers were needed to fight it.
Panic and disruption
Some experts warn that the outbreak could destabilize governments in the region. It is already causing widespread panic and disruption. On Saturday, Guinea said it had closed its borders with Sierra Leone and Liberia in a bid to halt the virus’ spread.
In Liberia, riot police raced to quell a demonstration blocking Liberia’s busiest highway Saturday as an angry crowd protested the government’s delays in collecting the bodies of Ebola victims.
Several bodies had been lying by the roadside for two days in the central town of Weala, 50 miles from the capital, Monrovia, and no government agency had picked them up, residents said. The government has ordered that all those killed by Ebola be cremated amid community opposition to neighborhood burials for fear of further contamination.
Doctors also worry that deaths from malaria, dysentery and other diseases could shoot up as Ebola drains resources from weak health systems. Health-care workers, already in short supply, have been hit hard by the outbreak: 145 have been infected, and 80 of them have died.
Past Ebola outbreaks have been snuffed out, often within a few months. How did this one spin so far out of control? It is partly a consequence of modernization in Africa, and perhaps a warning that future outbreaks — which are inevitable — will pose tougher challenges. Unlike most previous outbreaks, which occurred in remote, localized spots, this one began in a border region where roads have been improved and people travel a lot. In this case, the disease was on the move before health officials knew it had struck.
Also, this part of Africa had never seen Ebola before. Health workers did not recognize it and had neither the training nor the equipment to avoid infecting themselves or other patients. Hospitals in the region often lack running water and gloves, and can be fertile ground for epidemics.
Public-health experts acknowledge that the initial response, locally and internationally, was inadequate.
“That’s obviously the case,” said Dr. Tom Frieden, director of the Centers for Disease Control and Prevention (CDC). “Look at what’s happening now.”
He added: “A couple of months ago, there was a false sense of confidence that it was controlled, a stepping back, and then it flared up worse than before.”
Health experts have grown increasingly confident in recent years that they can control Ebola, Frieden said, based on success in places like Uganda.
But those successes hinged on huge education campaigns to teach people about the disease and persuade them to go to treatment centers. Much work also went into getting people to change funeral practices that involve touching corpses, which are highly infectious.
Hard to contain
But in West Africa, Ebola was unknown.
In some areas, frightened and angry people have attacked health workers and even accused them of bringing in disease.
“Early on in the outbreak, we had at least 26 villages or little towns that would not cooperate with responders in terms of letting people into the village, even,” said Gregory Hartl, a WHO spokesman.
In mid-March, Guinea’s Ministry of Health asked Doctors Without Borders for help in Guéckédou.
At first, the group’s experts suspected Lassa fever, a viral disease endemic in West Africa. But this illness was worse. Isolation units were set up, and tests confirmed Ebola.
Like many African cities and towns, this region hums with motorcycle taxis and minivans crammed with passengers.
The mobility and now the sheer numbers of infected people make the basic work of containing the disease a monumental task. The only way to stop an outbreak is to isolate infected patients, trace all their contacts, isolate the ones who get sick and repeat the process until, finally, there are no more cases.
But how do you do that when there can easily be 500 names on the list of contacts who are supposed to be tracked down and checked for fever every day for 21 days?
“They go to the field to work their crops,” said Monia Sayah, a nurse sent in by Doctors Without Borders. “Some have phones, but the networks don’t always work. Some will say, ‘I’m fine; you don’t have to come,’ but we really have to see them and take their temperature. But if someone wants to lie and take Tylenol, they won’t have a temperature.”
Tracing the disease
As is often the case in Ebola outbreaks, no one knows how the first person got the disease or how the virus found its way to the region. The virus infects monkeys and apes, and some previous epidemics are thought to have begun when someone was exposed to blood while killing or butchering an infected animal. Cooking will destroy the virus, so the risk is not in eating the meat, but in handling it raw. Ebola is also thought to infect fruit bats without harming them, so the same risks apply to butchering bats. Some researchers also think that people might become infected by eating fruit or other uncooked foods contaminated by droppings from infected bats.
Once people become ill, their bodily fluids can infect others, and they become more infectious as the illness progresses. The disease does not spread through the air like the flu; contact with fluids is necessary, usually through the eyes, nose, mouth or cuts in the skin. One drop of blood can harbor millions of viruses, and corpses become like virus bombs.
A research team that studied the Guinea outbreak traced the disease back to the 2-year-old who died in Guéckédou and published a report in The New England Journal of Medicine. He and his relatives were never tested to confirm Ebola, but their symptoms matched it and they fit into a pattern of transmission that included other cases confirmed by blood tests.
But no one can explain how the child could have become the first person infected. Contaminated fruit is one possibility. An injection with a contaminated needle is another.
Sylvain Baize, part of the team that studied the Guinea outbreak and head of the national reference center for viral hemorrhagic fevers at the Pasteur Institute in Lyon, France, said there might have been an earlier case that went undiscovered, before the 2-year-old.
“We suppose that the first case was infected following contact with bats,” he said. “Maybe, but we are not sure.”
Dr. Fazlul Haque, deputy representative of UNICEF in Liberia, said that after a few cases there in March and April, health workers thought the disease had gone away. But it came roaring back about a month later.
“It reappeared, and this time, it came in a very big way,” he said. “The rate of increase is very high now.”
From July 30 to Aug. 6, Liberia’s government reported more than 170 new cases and more than 90 deaths. “Currently, our efforts are not enough to stop the virus,” Haque said.
He added that most health agencies believed the true case numbers to be far higher, in part because locals were not coming forward when relatives fell ill, and because detection by the health authorities had been weak. Rukshan Ratnam, a spokesman for UNICEF in Liberia, said some families had hidden their sick to avoid sending them to isolation wards or out of shame stemming from traditional beliefs that illness is a punishment for doing something wrong.
Haque said the tracing of cases, crucial for the containment of the disease, was moving too slowly to keep up with new infections. Seven counties have confirmed cases, and the government has deployed security forces in Lofa County, where Liberia’s first case was detected, he said. But the government has given leave to nonessential employees in those areas, so it is not clear how they will have the staffing to isolate the sick. Some hospitals have closed because so many health workers have fallen ill.
Liberia has closed markets and many border crossings. It has said testing and screening will be done at immigration checkpoints.
But on Thursday, at a checkpoint staffed by at least 30 soldiers in Klay, Bomi County, there was no screening — just a blockade and a line of trucks loaded with bags of charcoal, plantains and potato greens.
Hilary Wesseh, a truck driver who was sucking the last drops of juice out of a small lime, said he had been stuck there for two days.
“They are holding us hostage,” he said.
By June and July, Sierra Leone was becoming the center of the outbreak. At the government hospital in Kenema, Dr. Sheik Umar Khan was leading the efforts to treat patients and control the epidemic.
But he was desperate for supplies: chlorine for disinfection, gloves, goggles, protective suits, rudimentary sugar and salt solutions to fight dehydration and give patients a chance to survive. Early in July, he emailed friends and former medical-school classmates in the United States, asking for their help and sending a spreadsheet listing what he needed, and what he had. Many of the lines in the “available” column were empty. One of his requests was for body bags: 3,000 adult, 2,000 child.
Before his friends could send the supplies, Khan contracted Ebola. He died July 29.
Material from The Associated Press is included in this report.