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KIEV, Ukraine — Public protests thundered into a full-throttle civil uprising in Ukraine on Sunday, as hundreds of thousands of protesters answered President Viktor Yanukovych’s dismissiveness with their biggest rally so far, demanding that he and his government resign.

At the height of the unrest Sunday night, a seething crowd toppled and smashed a statue of Lenin, the most prominent monument to the Communist leader in Kiev. The act was heavy with symbolism, underscoring the protesters’ rage at Russia over its role in the events that first prompted the protests: Yanukovych’s abrupt refusal to sign sweeping political and free-trade agreements with the European Union.

After an electrifying assembly in Independence Square in the center of Kiev, the main focus of the protests, the huge crowd surged across the capital, erecting barriers to block the streets around the presidential headquarters and pitching huge tents in strategic intersections. They were not challenged by the police, who have largely disengaged since their bloody crackdown on a group of protesters Nov. 30 sharply increased outrage at the government.

International concern over the unrest in Ukraine appeared to deepen Sunday, as U.N. Secretary-General Ban Ki-moon telephoned Yanukovych and Western leaders continued to call on him to respond to the demonstrators’ demands. The EU has been eager to draw Ukraine, a nation of 46 million, into closer alliance with the West, while Russia has sought to safeguard its major economic and political interests in its close neighbor. Making the crisis more acute, Ukraine is teetering on the verge of bankruptcy and is desperate for financial assistance from abroad.

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The spreading disorder set off a new round of speculation that Yanukovych would declare a state of emergency and potentially turn again to force by ordering the removal of demonstrators who have occupied Independence Square and several public buildings, including Kiev’s City Hall. There were reports Sunday that the security services were preparing to bring charges of treason against three opposition leaders in parliament who have been at the forefront of the demonstrations.

One of those leaders, Arseniy P. Yatsenyuk, of the opposition Fatherland party, called for mass civil disobedience if Yanukovych tried to impose martial law.

“In the case that a state of emergency is declared, everyone should go to Maidan,” Yatsenyuk said, referring to Independence Square.

Yanukovych only added to the demonstrators’ anger by stopping on his way back from China on Friday to meet with President Vladimir Putin of Russia in Sochi, the Russian resort city. Rumors immediately began swirling that Yanukovych had cut a secret economic deal with Putin that would lead to Ukraine joining a customs union with Russia, Belarus and Kazakhstan, a step that many Ukrainians believe would deliver their country’s future into the Kremlin’s hands. Both governments denied the rumors, but the protesters do not trust either Putin or Yanukovych, and opposition leaders used the matter Sunday to whip up the crowd in Kiev.

“Today, they fall on their knees in front of the president of Russia and surrender us to the customs union,” said Oleg Tyagnibok, the leader of the nationalist Svoboda Party. “We demand to make public what these secret negotiations were about. They bring us back to the time of Stalinism. Is this 1937?”

Later, as the Lenin statue was pulled down and men took turns splintering it to bits with a sledgehammer, protesters twice sang the national anthem, removing their caps and covering their hearts with their hands. One of the hammerers wore his hair in a Mohawk; another was a priest in black vestments. Onlookers shielded their faces from the flying granite chips as they cheered them on, yelling: “Good job, guys.”

A spokesman for Prime Minister Mykola Azarov called the statue’s destruction “barbaric.”

Yanukovych’s decision not to sign the accords with the EU, reversing more than a year of promises to complete them, touched off the protests Nov. 21. But a series of other events have not only helped the protest leaders gather larger and larger crowds, but confounded Yanukovych’s efforts to tamp them down. The protest movement was injected with a new wave of popular fury after the police’s crackdown on a few hundred protesters Nov. 30 — violence that was unheard-of even during the Orange Revolution protests of 2004.

Support for Yanukovych and the government among his usual allies did appear to be weakening. Some of the wealthy businessmen who control Ukrainian television channels have allowed them to broadcast full unfettered coverage of the protests, which has made the crowds larger still. So has aggressive organizing on social media by protest leaders.

Yanukovych appeared to hope that the protests would fizzle if he dismissed them as the work of his political opponents; instead, protesters have called all the louder for his resignation, saying he is aloof and unresponsive.

The protesters have transformed Independence Square over the past week by erecting a vast and growing tent encampment. The teeming crowds on Sunday included parents with children on their shoulders, students wearing face paint in the blue and yellow of the national flag, and volunteers handing out steaming cups of tea and other refreshments. Representatives of all branches of the Ukrainian Orthodox Church blessed them from the stage, except for the Moscow Patriarchate, which is loyal to Russia.

Many protesters Sunday said it was the police violence, even more than the reversal on the European accords, that angered them.

“We are not a political family,” said Oleksandr Ruchko, a computer programmer who was with his wife, Olena. “But the shove from the government, when they beat students and innocent people, that really drove us to come out.”

“The question of Europe doesn’t motivate everybody,” he said. “We hope the people will be heard, and the government will resign.”

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