After potentially serious back-to-back laboratory accidents, federal health officials said Friday that they had temporarily closed the flu and anthrax laboratories at the Centers for Disease Control and Prevention (CDC) in Atlanta and halted shipments of all infectious agents from the agency’s highest-security labs.
The accidents, and the CDC’s response to them, could have important consequences for the many laboratories that store high-risk agents and the few that, even more controversially, specialize in making them more dangerous for research purposes.
If the CDC — which the agency’s director, Dr. Thomas Frieden, called “the reference laboratory to the world” — had multiple accidents that could, in theory, have killed employees and members of the public, there will undoubtedly be calls for stricter controls on other university, military and private laboratories.
In one episode last month, up to 62 CDC employees may have been exposed to live anthrax bacteria after potentially infectious samples were sent to laboratories unequipped to handle them. Employees not wearing protective gear worked with bacteria that were supposed to have been killed but may not have been. All the employees were offered a vaccine and antibiotics, and the agency said it believed no one was in danger.
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In a second accident, disclosed Friday, a CDC lab accidentally contaminated a relatively benign flu sample with a dangerous H5N1 bird-flu strain that has killed 386 people since 2003. Fortunately, a U.S. Agriculture Department laboratory realized that the strain was more dangerous than expected and alerted the CDC, but only weeks after the episode occurred.
The bird-flu incident, which began at the CDC’s influenza laboratory in Atlanta, was discovered May 23 but wasn’t reported to senior CDC officials until Monday. Frieden didn’t hear of the situation until Wednesday.
When asked about the six-week delay in reporting the incident, Frieden said: “I can think of no valid explanation.”
In addition to those mistakes, Frieden also announced Friday that two of six vials of smallpox recently found stored in a National Institutes of Health (NIH) laboratory since 1954 contained live virus capable of infecting people.
All the samples will be destroyed as soon as the genomes of the virus in them can be sequenced. The NIH will scour its freezers and storerooms for other dangerous material, he said.
“These events revealed totally unacceptable behavior,” Frieden said. “They should never have happened. I’m upset, I’m angry, I’ve lost sleep over this, and I’m working on it until the issue is resolved.”
The anthrax and flu labs will remain closed until new procedures are imposed, Frieden said. For the flu lab, that will be finished in time for vaccine preparation for next winter’s flu season, he said.
Frieden suggested that the accidents had implications for labs beyond his agency, arguing that the world needs to reduce to absolute minimums the number of labs handling dangerous agents, the number of staff involved and the number of agents circulating.
Scientists doing the most controversial work — efforts to make pathogens more lethal or more transmissible — say the research helps predict mutations that might arise in nature so that vaccines can be designed. But other scientists say that creating superstrains is unacceptably dangerous because lab accidents are more common than is often acknowledged, as Frieden’s announcement indicated.
The revelations at the CDC renewed calls for a moratorium from opponents of such “gain of function” research.
“This has been a nonstop series of bombshells, and this news about contamination with H5N1 is just incredible,” said Peter Hale, founder of the Foundation for Vaccine Research, which lobbies for more funding for vaccines but opposes “gain of function” research. “You can have all the safety procedures in the world, but you can’t provide for human error.”
At the CDC, Frieden said, employees who knowingly failed to follow procedures or who failed to report dangerous incidents will be disciplined. A committee of experts will be convened to revise procedures.
In the flu-related incident, a CDC lab accidentally contaminated a sample of less dangerous H9N2 bird flu, which it was preparing for shipment to an Agriculture Department laboratory, with the H5N1 bird-flu strain.
Despite the delay in reporting the problem, Frieden said, “We have a high degree of confidence that no one was exposed.” The flu material was handled in high-biosafety-level labs in both agencies, and the workers wore breathing apparatuses.
In theory, the flu-related accident could have been much worse than the anthrax one.
Anthrax can kill those who inhale it, but is not normally transmitted between humans, so an infected laboratory worker presumably could not have gone home and passed it on. H5N1 bird flu has killed about 60 percent of those known to have caught it, almost always after contact with poultry. Although it does not easily jump from person to person, it is thought to have done so several times.
The anthrax episode took place June 5 in the agency’s bioterrorism rapid-response lab as part of testing a new mass spectrometry method.
The new CDC report found several errors: A scientist used a dangerous anthrax strain when a safer one would have sufficed; had not read relevant studies; and used an unapproved chemical killing method.
The error was discovered by accident. The door to an autoclave that would have sterilized samples taken for safety tests was stuck, so they were left in an incubator for days longer than normal. Only then did a lab technician notice that bacteria believed to be dead were growing.
Material from the McClatchy Washington Bureau is included in this report.